Mangosteen Xanthones Research: Alpha-Mangostin

Mangosteen contains the xanthone alpha-mangostin, one of more than 40 of these natural chemical compounds found in the "Queen of Fruits".

Scientists found that xanthones have powerful medicinal properties.

Their studies proved that these natural compounds contain healing properties that help sustain the immune system, support microbiological balance, promote positive mental health, and improve joint flexibility.

Alpha mangostin, one of the major and much-studied xanthones found in Mangosteens, was proven to be a stronger antioxidant than others long known for their antioxidant capabilities.

Tumors and Cancer

In one scientific study, alpha mangostin was found to possess potent anti-tumor and anti-cancer properties and that longer exposure to it might help suppress the development of tumors.

In another study on alpha-mangostin's effects on human leukemia cells, results indicated that this xanthone would be helpful in the prevention and treatment of cancer.


Alpha-mangostin was also proven to have strong antibacterial activity against Staphylococcus aureus.

Scientists demonstrated alpha-mangostin's activity against vancomycin-resistant Enterococci (VRE) and methicillin-resistant Staphylococcus aureus.

They found that alpha-mangostin, alone or in combination with gentamicin against vancomycin-resistant Enterococci (VRE), and in combination with vancomycin hydrochloride against methicillin-resistant Staphylococcus aureus (MRSA), might be useful in controlling VRE and MRSA infections.

Further studies showed that this xanthone works well with and enhances the effects of other commercially-available antibiotics such as ampicillin and minocycline.

In another laboratory experiment, scientists studied the anti-mycobacterial activity of alpha-mangostin and found that it prossesses strong inhibitory effects against Mycobacterium tuberculosis.


Researchers also found that alpha-mangostin is a histaminergic receptor-blocking agent --- it is effective in preventing or stopping allergies.

See also:

Mangosteen Xanthones Research: Gamma-Mangostin
Why does gamma-mangostin occupy a very special place in Mangosteen's arsenal of natural healing compounds? Scientists provide the answer.